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Another Blow to Magic Bullet Drugs: Statins Impair
Brains
Statin drugs can reduce soaring cholesterol levels, according to
countless ads touting these supposed "wonder" drugs, that means they are
brimming with health benefits because they lower the risk of
cardiovascular disease. |
The problem is a host of
side effects from eye problems and muscle pain to heart arrhythmias and
liver disorders have been linked to these widely prescribed medications.
Now comes research by an Iowa State University scientist that strongly
suggests statins also could be robbing brains of thinking power and
memory by doing exactly what they are supposed to do -- reduce
cholesterol.
It turns out that statins inhibit not only the liver from making
cholesterol but may also block the brain from making cholesterol. That's
a serious consequence, according to Yeon-Kyun Shin, a biophysics
professor in the department of biochemistry, biophysics and molecular
biology at Iowa State, because cholesterol is vital for healthy and
optimum brain function. "If you deprive cholesterol from the brain, then
you directly affect the machinery that triggers the release of
neurotransmitters. Neurotransmitters affect the data-processing and
memory functions. In other words, how smart you are and how well you
remember things," said Dr. Shin in a statement to the media.
In a study published in the February issue of the journal Proceedings
of the National Academy of Sciences, Dr. Shin and colleagues tested
the activity of the neurotransmitter-release processes of brain cells
without cholesterol present to see how well they functioned. Then
cholesterol was placed in the system and the scientists measured the
transmitter function again. The result? Cholesterol increased the
neurotransmitter function by five times.
"Our study shows there is a direct link between cholesterol and the
neurotransmitter release. We know exactly the molecular mechanics of
what happens in the cells. Cholesterol changes the shape of the protein
to stimulate thinking and memory," Dr. Shin said in the press statement.
"If you try to lower the cholesterol by taking medicine that is
attacking the machinery of cholesterol synthesis in the liver, that
medicine goes to the brain too. And then it reduces the synthesis of
cholesterol which is necessary in the brain."
However, just because cutting down on cholesterol in the brain may mess
up memory and cognitive skills, it doesn't mean that more cholesterol in
the blood will make you more intelligent and able to remember more
facts. That's because no matter how much cholesterol is in your diet,
the cholesterol in the blood doesn't cross over the blood brain barrier.
In addition, by loading a diet with saturated fat from animal products
and junk food, too much low-density lipoprotein (LDL), often called
"bad" cholesterol, can build up in cells and cause hardening of arterial
walls contributing to strokes and heart disease -- unless you have
enough high-density lipoprotein (HDL), or "good" cholesterol, to keep
LDL out of cells. Fortunately, there are many proven ways to lower the
"bad" artery logging cholesterol without resorting to statin drugs. For
example, the Mayo Clinic web site notes garlic, ground flaxseed, barley
and artichoke extract may be helpful in keeping cholesterol levels in
healthy balance.
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